01 - 5 - 2014 |
D4.2 - Collection Cartridge Module for ENP Identification by ICP-MS
The SMART-NANO consortium successfully demonstrated the use of ICP-MS for the hypersensitive identification and partial quantification of ENP in two configurations (off-line and on-line). The direct on-line coupling of AF4 to ICP-MS is a major accomplishment and will allow using ICP-MS as a hypersensitive quantitative detector for several metal-based ENPs. Specifically, the detection of titanium at ppb levels has been demonstrated for titanium dioxide nanoparticles in a model sunscreen matrix, both in the on-line and off-line configuration. The particle size distribution of a polydispersed silver nanoparticles mixture has also been demonstrated in the on-line configuration at ppb levels. In addition, single particle detection via ICP-MS has been achieved in the case of silver nanoparticles at ppt sensitivity. A collection cartridge module for easy and safe transfer of AF4-separated fractions to ICP-MS measurement facilities has been demonstrated.