Programme: FP7 - NMP.2011.1.3-1 - Contract n°280779

29 - 2 - 2016 |

Partner publication: Inverse supercritical fluid extraction as a sample preparation method for the analysis of the nanoparticle content in sunscreen agents

Smartnano partners recently published the article "Inverse supercritical fluid extraction as a sample preparation methodfor the analysis of the nanoparticle content in sunscreen agents". The Smartnano team wishes to congratulate our partners D. Müller, S. Cattaneo, F. Meier, R. Welz, T. de Vries, M. Portugal-Cohen, D. C. Antonio, C. Cascio, L. Calzolai, D. Gilliland, Mello.

The full article is available on scienceridect


We demonstrate the use of inverse supercritical carbon dioxide (scCO2) extraction as a novel method of sample preparation for the analysis of complex nanoparticle-containing samples, in our case a model sunscreen agent with titanium dioxide nanoparticles. The sample was prepared for analysis in a simplified process using a lab scale supercritical fluid extraction system. The residual material was easily dispersed in an aqueous solution and analyzed by Asymmetrical Flow Field-Flow Fractionation (AF4) hyphenated with UV- and Multi-Angle Light Scattering detection. The obtained results allowed an unambiguous determination of the presence of nanoparticles within the sample, with almost no background from the matrix itself, and showed that the size distribution of the nanoparticles is essentially maintained. These results are especially relevant in view of recently introduced regulatory requirements concerning the labeling of nanoparticle-containing products. The novel sample preparation method is potentially applicable to commercial sunscreens or other emulsion-based cosmetic products and has important technological advantages over currently used sample preparation techniques involving organic solvents.